Thailanstatin A

CAS No. 1426953-21-0

Thailanstatin A( —— )

Catalog No. M28204 CAS No. 1426953-21-0

Thailanstatin A is an ultra-potent inhibitor of eukaryotic RNA splicing ( IC 50 =650 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 294 Get Quote
5MG 521 Get Quote
10MG 746 Get Quote
25MG 1143 Get Quote
100MG Get Quote Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    Thailanstatin A
  • Note
    Research use only, not for human use.
  • Brief Description
    Thailanstatin A is an ultra-potent inhibitor of eukaryotic RNA splicing ( IC 50 =650 nM).
  • Description
    Thailanstatin A is an ultra-potent inhibitor of eukaryotic RNA splicing ( IC 50 =650 nM). Thailanstatin A exerts effects via non-covalent binding to the SF3b subunit of the U2 snRNA subcomplex of the spliceosome and shows low-nM to sub-nM IC 50 s against multiple cancer cell lines. Thailanstatin A, a payload for ADCs, is conjugated to the lysines on trastuzumab yielding “linker-less” ADC .(In Vitro):Thailanstatin A (TST-A) is a potent antiproliferative natural product discovered by our group from Burkholderia thailandensis MSMB43 . Thailanstatin A (DU-145, NCI-H232A, MDA-MB-231 and SKOV-3 cells) exhibits potent antiproliferative activities with GI 50 s in the single nM range (1.11-2.69 nM) .
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    AChR|Antifection|COX-2|PPAR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1426953-21-0
  • Formula Weight
    535.63
  • Molecular Formula
    C28H41NO9
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (466.74 mM)
  • SMILES
    C[C@@H](/C=C\C(N[C@H]1[C@@H](C)O[C@@H](C/C=C(\C)/C=C/[C@H]([C@H]2O)O[C@H](CC(O)=O)C[C@]22OC2)[C@@H](C)C1)=O)OC(C)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Bourjot M, et al. Chemical constituents of Anacolosa pervilleana and their antiviral activities. Fitoterapia. 2012 Sep;83(6):1076-80.
molnova catalog
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