Thailanstatin A ( —— )

Catalog No. M28204 CAS No. 1426953-21-0

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Thailanstatin A
Note

Research use only, not for human use.
Brief Description

Thailanstatin A is an ultra-potent inhibitor of eukaryotic RNA splicing ( IC 50 =650 nM).
Description

Thailanstatin A is an ultra-potent inhibitor of eukaryotic RNA splicing ( IC 50 =650 nM). Thailanstatin A exerts effects via non-covalent binding to the SF3b subunit of the U2 snRNA subcomplex of the spliceosome and shows low-nM to sub-nM IC 50 s against multiple cancer cell lines. Thailanstatin A, a payload for ADCs, is conjugated to the lysines on trastuzumab yielding “linker-less” ADC .(In Vitro):Thailanstatin A (TST-A) is a potent antiproliferative natural product discovered by our group from Burkholderia thailandensis MSMB43 . Thailanstatin A (DU-145, NCI-H232A, MDA-MB-231 and SKOV-3 cells) exhibits potent antiproliferative activities with GI 50 s in the single nM range (1.11-2.69 nM) .
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

AChR;Antifection;COX-2;PPAR
Research Area

——
Indication

——

CAS Number

1426953-21-0
Formula Weight

535.6
Molecular Formula

C28H41NO9
Purity

>98% (HPLC)
Solubility

——
SMILES

C[C@@H](/C=C\C(N[C@H]1[C@@H](C)O[C@@H](C/C=C(\C)/C=C/[C@H]([C@H]2O)O[C@H](CC(O)=O)C[C@]22OC2)[C@@H](C)C1)=O)OC(C)=O
Chemical Name

——

1.Bourjot M, et al. Chemical constituents of Anacolosa pervilleana and their antiviral activities. Fitoterapia. 2012 Sep;83(6):1076-80.

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